منابع مشابه
Assessment of kidney function for drug dosing.
The effort to improve the identification and management of patients with chronic kidney disease (CKD) is based on implementing more precise means of assessing kidney function and kidney damage in the clinical setting. Over the past decade, the clinical chemistry community has adopted routine reporting of estimated GFR (eGFR) calculated from the Modification of Diet in Renal Disease (MDRD) Study...
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Dear Editor, Dabigatran etexilate is commonly used for the prevention of stroke in patients with nonvalvular atrial fibrillation, and is as effective as and safer than warfarin.1 However, there is no reversal agent despite serious outcomes of bleeding complication,2 with hemodialysis being the only reliable option. Idarucizumab has recently been developed as a genuine reversal agent of dabigatr...
متن کاملIdarucizumab for Dabigatran Reversal.
BACKGROUND Specific reversal agents for non-vitamin K antagonist oral anticoagulants are lacking. Idarucizumab, an antibody fragment, was developed to reverse the anticoagulant effects of dabigatran. METHODS We undertook this prospective cohort study to determine the safety of 5 g of intravenous idarucizumab and its capacity to reverse the anticoagulant effects of dabigatran in patients who h...
متن کاملWarfarin dosing in patients with impaired kidney function.
BACKGROUND In patients with kidney impairment, warfarin, a drug metabolized primarily by the cytochrome P-450 system, is initiated at similar doses and managed similarly as in the general medical population. Unfortunately, few data exist to guide dose adjustment in patients with decreased kidney function. Here, we determine the degree of warfarin dose reduction associated with kidney impairment...
متن کاملGut Microbiota and Tacrolimus Dosing in Kidney Transplantation
Tacrolimus dosing to establish therapeutic levels in recipients of organ transplants is a challenging task because of much interpatient and intrapatient variability in drug absorption, metabolism, and disposition. In view of the reported impact of gut microbial species on drug metabolism, we investigated the relationship between the gut microbiota and tacrolimus dosing requirements in this pilo...
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ژورنال
عنوان ژورنال: American Journal of Kidney Diseases
سال: 2018
ISSN: 0272-6386
DOI: 10.1053/j.ajkd.2017.08.012